KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
39.7
Human Site:
Y349
Identified Species:
62.38
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
Y349
K
G
G
R
H
V
D
Y
V
V
D
Q
V
V
G
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y357
K
G
G
R
H
V
D
Y
V
V
D
Q
V
V
G
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
Y343
K
G
G
R
H
V
D
Y
V
V
D
Q
V
V
G
Dog
Lupus familis
XP_534241
2041
231068
Y767
K
G
G
R
H
V
D
Y
V
V
D
Q
V
V
G
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
Y337
K
G
G
R
H
V
D
Y
V
V
D
Q
V
V
S
Rat
Rattus norvegicus
P41516
1526
173202
Y326
K
G
G
R
H
V
D
Y
V
A
D
Q
I
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
Y652
K
G
G
R
H
V
D
Y
V
V
D
Q
I
V
G
Chicken
Gallus gallus
O42131
1627
183228
Y354
K
G
G
R
H
V
D
Y
V
V
D
Q
V
V
G
Frog
Xenopus laevis
NP_001082502
1579
178601
Y326
K
G
G
R
H
V
D
Y
V
A
D
Q
I
V
T
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
Y348
K
G
G
R
H
I
D
Y
I
V
D
Q
I
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
V280
V
A
N
E
R
W
E
V
A
C
C
P
S
D
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
T353
S
F
V
N
S
I
A
T
T
K
G
G
R
H
V
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
F281
G
S
K
G
V
K
V
F
L
N
G
K
R
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
L306
R
W
E
V
C
V
S
L
S
E
G
Q
F
Q
Q
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
K261
Y
L
K
S
L
E
K
K
R
Q
L
D
N
G
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
93.3
80
N.A.
93.3
100
80
80
N.A.
0
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
86.6
N.A.
100
100
86.6
100
N.A.
6.6
N.A.
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
7
0
7
14
0
0
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
7
7
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
67
0
0
0
67
7
0
7
0
% D
% Glu:
0
0
7
7
0
7
7
0
0
7
0
0
0
0
7
% E
% Phe:
0
7
0
0
0
0
0
7
0
0
0
0
7
0
0
% F
% Gly:
7
67
67
7
0
0
0
0
0
0
20
7
0
7
47
% G
% His:
0
0
0
0
67
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
0
0
0
14
0
0
7
0
0
0
27
0
0
% I
% Lys:
67
0
14
0
0
7
7
7
0
7
0
7
0
0
0
% K
% Leu:
0
7
0
0
7
0
0
7
7
0
7
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
7
0
0
0
0
0
7
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
7
0
74
0
7
7
% Q
% Arg:
7
0
0
67
7
0
0
0
7
0
0
0
14
0
7
% R
% Ser:
7
7
0
7
7
0
7
0
7
0
0
0
7
0
14
% S
% Thr:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
7
% T
% Val:
7
0
7
7
7
67
7
7
60
54
0
0
40
67
7
% V
% Trp:
0
7
0
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _